Question

Which of the following statement is not true for catalysis by approximation?

(a) Change in conformation 3D structure of protein from low activity form to high activity form

(b) To make reactants proximal to each other

(c) This proximity raises effective concentration over that of the reactants free in solution and lead to rate acceleration

(d) To quantify some proximity effects, model studies were carried out

This question was posed to me in homework.

This intriguing question comes from Mechanism of Enzyme Catalysis topic in chapter Enzyme Assay & Enzyme Catalysis of Enzyme Technology

Answer 1

The correct choice is (a) Change in conformation 3D structure of protein from low activity form to high activity form

Explanation: “Change in conformation 3D structure of a protein from low activity form to high activity form.” This is true for strain distortion and conformational change. Catalysis by approximation has the following features:

• To make reactants proximal to each other as they will be at the active site.

• This proximity raises effective concentration over that of the reactants free in solution and lead to rate acceleration.

• To quantify some proximity effects, model studies were carried out.