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The reaction in the diagram belongs to which type of catalysis?

(a) Strain distortion and conformational change

(b) Approximation catalysis

(c) Acid base catalysis

(d) Covalent catalysis

The question was posed to me during an online exam.

The origin of the question is Mechanism of Enzyme Catalysis topic in division Enzyme Assay & Enzyme Catalysis of Enzyme Technology

1 Answer

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Best answer
The correct option is (c) Acid base catalysis

The best explanation: The reaction represents the case of hydrolysis of acetyl imidazole which explains the acid base catalysis. The imidazole functions as a base catalyst in addition to OH. Catalysis by imidazole implies that the energy barrier for hydrolysis is lowered by proton itself. Therefore, the nuclepohilicity of the water molecule is enhanced without the generation of a high concentration of OH. The catalytic transition state is stabilized by avoiding the formation of unstable high energy species due to the hydrogen bond in the transition state.

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