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A type of catalysis which involves covalent intermediate transition state formation between the cationic electrophilic group in the enzyme and the electron rich portion of the substrate is referred to as ____________

(a) general acid-base catalysis

(b) electrophilic catalysis

(c) nucleophilic catalysis

(d) specific acid-base catalysis

I have been asked this question in an online interview.

My question comes from Enzyme Kinetics topic in chapter Enzyme Kinetics of Enzyme Technology

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Right answer is (b) electrophilic catalysis

The best I can explain: In most of the enzymatic reaction protons are involved. General and specific acid-base catalysis are types on acid-base catalysis. Nucleophilic catalysis involves donation of electrons from nucleophilic active site residues to a substrate forming a covalent adduct transition state intermediate. Whereas, electrophilic catalysis involves covalent intermediate transition state formation between the cationic electrophilic group in the enzyme and the electron rich portion of the substrate.

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