Question

The transition state cannot be achieved by using one of the following methods?

(a) Substrate collision theory

(b) Lock and key model

(c) Acid-base catalysis

(d) Covalent catalysis

This question was posed to me in homework.

I'm obligated to ask this question of Enzyme Kinetics in chapter Enzyme Kinetics of Enzyme Technology

Answer 1

Right answer is (b) Lock and key model

To explain I would say: By using lock and key model, the transition state cannot be achieved. Lock and key model proposes the fitting of substrate into the active site of the enzyme like a key fits into its lock. Substrate collision theory, acid-base catalysis and covalent catalysis are used to achieve the transition state required during enzyme catalysis.