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Which of the following cannot be detected by using angiotensin converting enzyme (ACE)?

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Which of the following cannot be detected by using angiotensin converting enzyme (ACE)?

(a) Sarcoidosis

(b) Hodgkin’s disease

(c) Tuberculosis

(d) Paget’s disease

This question was addressed to me in class test.

Question is from Diagnostic Use of Enzymes topic in section Enzymes of Enzyme Technology

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Correct choice is (d) Paget’s disease

To elaborate: In paget’s disease, the plasma alkaline phosphatase (ALP) levels are 10 to 25 times the normal upper limit. Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to active angiotensin II by cleaving histidine-leucine dipeptide from the carboxylic end of angiotensin I. Following can be detected by using ACE:

• Elevated levels in serum is a marker for sarcoidosis.

• ACE activity is elevated in other conditions such as Hodgkin’s disease, Tuberculosis, asbestosis, cirrhosis leprosy and gaucher’s disease.

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