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In which of the following bone diseases, the plasma alkaline phosphatase levels are 10 to 25 times the normal upper limit?

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In which of the following bone diseases, the plasma alkaline phosphatase levels are 10 to 25 times the normal upper limit?

(a) Bone cancer

(b) Rickets

(c) Fanconi’s syndrome

(d) Paget’s disease

I had been asked this question in examination.

This question is from Diagnostic Use of Enzymes in division Enzymes of Enzyme Technology

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The correct choice is (d) Paget’s disease

To elaborate: In paget’s disease, the plasma alkaline phosphatase (ALP) levels are 10 to 25 times the normal upper limit. Very high levels of ALP are observed in cases of bone cancer. In rickets and osteomalacia, moderate rises are observed in ALP levels. Slight to moderate rise of ALP is seen in fanconi’s syndrome and hyper parathyroidism.

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