Question

Which of the following is not true of feedback allosteric inhibition in multienzyme system?

(a) First enzyme of the sequence is regulatory allosteric enzyme

(b) The enzyme is inhibited by the end product of the multienzyme system

(c) Allosteric enzymes obey Miachelis-Menten kinetics

(d) The whole enzyme system slows down to bring the rate of production of its end product back into balance when the cell needs it

I have been asked this question during an interview for a job.

The origin of the question is Allosteric Enzyme in portion Enzymes of Enzyme Technology

Answer 1

The correct choice is (c) Allosteric enzymes obey Miachelis-Menten kinetics

Explanation: “Allosteric enzymes obey Miachelis-Menten kinetics.” This statement is not true for allosteric feedback inhibition. The following statements are true for feedback allosteric inhibition in multienzyme system:

• First enzyme of the sequence is regulatory allosteric enzyme.

• The enzyme is inhibited by the end product of the multienzyme system. Thus, the end product of the sequence acts as a specific inhibitor of the first regulatory enzyme in the sequence.

• The whole enzyme system slows down to bring the rate of production of its end product back into balance when the cell needs it. This type of regulation is called feedback allosteric inhibition.