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Which of the following is not a clinical application of creatine kinase isoenzyme?

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Which of the following is not a clinical application of creatine kinase isoenzyme?

(a) Hypothyroidism

(b) Damage of heart tissue

(c) Myopathy

(d) Leukemia

This question was addressed to me by my college professor while I was bunking the class.

The query is from Enzymes topic in chapter Enzymes of Enzyme Technology

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Correct answer is (b) Damage of heart tissue

Best explanation: Predominant elevation of LDH2 and LDH3 is seen in cases of leukemia. Hence Leukemia is not a clinical application of creatine kinase, but lactate dehydrogenase enzyme. Following are the clinical application of creatine kinase isoenzyme:

• Hypothyroidism shows an elevation CK activity, majorly CK3.

• Damage of heart tissue from myocardial infraction may detected my increased level of CK2 in blood.

• Myopathy and dystrophy has elevated levels of CK3 in serum.

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