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Which of the following is not true for creatine kinase?

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+1 vote
in Enzyme Technology by (55.0k points)
Which of the following is not true for creatine kinase?

(a) Its activity is greatest in striated muscle, brain and heart tissue

(b) It catalyzes L-lactate to pyruvate

(c) It is a dimer

(d) It has three isoenzymes

I have been asked this question during an internship interview.

I would like to ask this question from Enzymes in portion Enzymes of Enzyme Technology

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Right option is (b) It catalyzes L-lactate to pyruvate

Explanation: Following statements are true for creatine kinase:

• Its activity is greatest in striated muscle, brain and heart tissue

• It is a dimer which is made up of 2 polypeptide chains: muscle (M) type or brain (B) type.

• It has three isoenzymes: CK1, CK2, CK3.

It does not catalyze L-lactate to pyruvate, but creatinine to creatinine phosphate by ATP which a reversible phosphorylation reaction.

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