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Which of the following is not a clinical significance of cholinesterase?

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Which of the following is not a clinical significance of cholinesterase?

(a) Detection of abnormal cholinesterase variants

(b) Asbestosis

(c) Liver function test

(d) Measurement of exposure of organophosphorus compounds

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This is a very interesting question from Diagnostic Use of Enzymes topic in chapter Enzymes of Enzyme Technology

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The correct answer is (b) Asbestosis

Best explanation: Asbestosis is measured when there is elevation in angiotensin converting enzyme (ACE) activity. Serum cholinesterase are useful in the following ways:

• Detection of abnormal cholinesterase variants.

• Liver function test measures the synthetic capacity of liver. Decrease levels are observed in cases of acute chronic hepatitis and in advance cirrhosis and liver cancer.

• Measurement of exposure of organophosphorus compounds because of decreased activity of acetylcholinesterase.

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