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Prostate specific antigen: Prostate cancer:: Amylase: _____________

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Prostate specific antigen: Prostate cancer:: Amylase: _____________

(a) Liver cancer

(b) Leukemia

(c) Pancreatic cancer

(d) Ovarian cancer

The question was posed to me in exam.

My question comes from Diagnostic Use of Enzymes topic in portion Enzymes of Enzyme Technology

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The correct choice is (c) Pancreatic cancer

For explanation: Prostate specific antigen (PSA) is a glycoprotein with a mild protease activity. PSA is tumor marker for prostate cancer which detects stage and monitors treatment for the same. In the same way, amylase acts as marker for pancreatic cancer. Markers for liver cancer are aldolase, alkaline phosphatase, LDH, 5^I – nucleotidase and γ-glutamyl transferase. Markers for leukemia are alkaline phosphatase, LDH etc. For ovarian cancer, placental alkaline phosphatase acts as a marker.

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