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Which of the following is not associated with increase of LDH activity in urine?

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Which of the following is not associated with increase of LDH activity in urine?

(a) Megaloblastic anemia

(b) Chronic glomerulonephritis

(c) Diabetic nephrosclerosis

(d) Kidney malignancies

I had been asked this question in an internship interview.

The above asked question is from Enzymes topic in chapter Enzymes of Enzyme Technology

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Right choice is (a) Megaloblastic anemia

Explanation: Megaloblastic anemia cause the erythrocyte precursor cell to breakdown in the bone marrow resulting in large quantities of LDH1 and LDH2 isoenzyme. Hence it is not associated with increase of LDH activity in urine. Following are associated with increase of LDH activity in urine:  Chronic glomerulonephritis, diabetic nephrosclerosis, bladder and kidney malignancies.

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