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An increase in serum level of LDH1 relative to LDH2 is an indication of ___________

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An increase in serum level of LDH1 relative to LDH2 is an indication of ___________

(a) muscular dystrophy

(b) leukemia

(c) myocardial infarction

(d) hepatitis with jaundice

The question was posed to me during a job interview.

This interesting question is from Enzymes in chapter Enzymes of Enzyme Technology

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Right choice is (c) myocardial infarction

For explanation I would say: An increase in serum level of LDH1 relative to LDH2 is an indication of myocardial infarction. During muscular dystrophy, LDH5 activity is said to increase moderately. Predominant elevation of LDH2 and LDH3 is seen in cases of leukemia. Majorly, LDH3 is elevated due to malignancy of many tissues. LDH5 activity increase is seen during liver diseases like toxic hepatitis with jaundice.

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