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Which of the enzyme ATP does not act as an inhibitor?

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Which of the enzyme ATP does not act as an inhibitor?

(a) Isocitrate dehydrogenase

(b) Phosphofructokinase-1

(c) Glycogen phosphorylase

(d) Fructose-1,6- bisphosphatase

The question was posed to me by my college professor while I was bunking the class.

This key question is from Allosteric Enzyme topic in portion Enzymes of Enzyme Technology

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Best answer
Correct option is (d) Fructose-1,6- bisphosphatase

The explanation: For, fructose-1,6- bisphosphatase, ATP does not act as an inhibitor, but activator in gluconeogenesis pathway. ATP is used as inhibitor for the following enzymes:

• Isocitrate dehydrogenase in the TCA cycle.

• Phosphofructokinase-1 in glycolysis cycle.

• Glycogen phosphorylase in glycogenolysis.

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