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Lock and key model was proposed by ______________ in 1890.

(a) Henri

(b) Miachelis and Menten

(c) Emil Fischer

(d) Daniel Koshland

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This interesting question is from Enzyme Kinetics in division Enzyme Kinetics of Enzyme Technology

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Correct option is (c) Emil Fischer

The best I can explain: Lock and key model was proposed by Emil Fischer in 1890. Whereas Daniel Koshland proposed induced fit model in 1958. Henri in 1903 and Miachelis and Menten in 1913 proposed kinetic models for enzyme catalyzed reaction. The main difference is that Miachelis and Menten did a strong experimental work than Henri to prove that an enzyme catalyzing single substrate reaction will possess a hyperbolic curve.

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