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Daniel Koshland proposed a model for enzyme’s reaction mechanism in 1958 which is termed as __________

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Daniel Koshland proposed a model for enzyme’s reaction mechanism in 1958 which is termed as __________

(a) Induced fit model

(b) Lock and key model

(c) Henri kinetic model

(d) Miachelis Menten kinetic model

This question was addressed to me in final exam.

The doubt is from Enzyme Kinetics in section Enzyme Kinetics of Enzyme Technology

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The correct answer is (a) Induced fit model

Explanation: Henri and Michalis Menten kinetic model was proposed in 1903 and 1913 respectively. The main difference is that Miachelis and Menten did a strong experimental work to prove that enzyme substrate catalyzed reaction will possess a hyperbolic curve. Daniel Koshland proposed induced fit model. Whereas, Emil Fischer proposed lock and key model.

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