Question

Which of the following is not explained by molecular orbital steering?

(a) The juxtaposition of the side chain groups of amino-acid and the reactive groups of the substrate is not sufficient for proper catalysis

(b) Overwhelm the vander waals repulsive forces that happen commonly between them

(c) The active residues should guide the groups in the substrate for exact interaction by thermal vibration due to elevated temperature

(d) Thermal vibration create motion in the active site amino acid side chain that direct reactive groups in the substrate to interact

The question was posed to me in an online quiz.

Origin of the question is Enzyme Kinetics in chapter Enzyme Kinetics of Enzyme Technology

Answer 1

Right choice is (c) The active residues should guide the groups in the substrate for exact interaction by thermal vibration due to elevated temperature

The explanation is: Overwhelm the vander waals repulsive forces that happen commonly between them is not explained by molecular orbital steering. It is a part of substrate collision theory. Molecular orbital steering explains the following:

* The juxtaposition of the side chain groups of amino-acid and the reactive groups of the substrate is not sufficient for proper catalysis.

* The active residues should guide the groups in the substrate for exact interaction by thermal vibration due to elevated temperature.

* Thermal vibration create motion in the active site amino acid side chain that direct reactive groups in the substrate to interact.