Right choice is (c) \(V_0=K_m \frac{V_0}{S_0}+V_{max}\)

Best explanation: The Lineweaver Burk equation has its own limitations due to the following reasons:

The extrapolation of graph to determine the -1/Km reaches the edge of the paper such that, the accurate value is unable to calculate.

The -1/Km value calculated for low substrate concentrations are seemed to be inaccurate for most times.

The linearity of the graph for calculating the -1/Km value is not clear.

To overcome these, Eadie-Hofstee plot equation was designed. The equation is

\(V_0=K_m \frac{V_0}{S_0} + V_{max}\) where,

V0 = initial velocity, Vmax = maximum rate, Km = Miachelis Menten constant and [S] = substrate concentration.