Question

Which of the following is not true for substrate collision theory?

(a) Both enzyme and substrate stumble upon each other

(b) Both enzyme and substrate provide good molecular orbital interactions

(c) Specificity of the substrate binding site

(d) Both enzyme and substrate should be flexible in forming transition states

This question was addressed to me in an online quiz.

I'd like to ask this question from Enzyme Kinetics in chapter Enzyme Kinetics of Enzyme Technology

Answer 1

The correct answer is (c) Specificity of the substrate binding site

To explain: Specificity of the substrate binding site comes into picture when dealing with active site. The following is essential for forming transition state by substrate collision theory:

* Stumble upon each other through proper diffusion limited collision.

* Good molecular orbital interactions by enduring the changes in the medium.

* Overwhelm the vander waals repulsive forces that happen commonly between them.

* Flexibility in forming transition states through proper interactions.