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In FPLC, the sample separates into various zones of sample components and is referred to as ________

(a) retention time

(b) peaks

(c) bands

(d) pKa

I got this question in an internship interview.

This intriguing question originated from Enzymes Purification in portion Enzymes Purification of Enzyme Technology

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Correct choice is (c) bands

To explain I would say: pKa is the pH at which half the groups are ionized. Retention time is the time at specific analytes elute out. Peaks are formed as result in chromatographs. Peaks and retention time is seen during HPLC. In FPLC, the sample is introduced and carried into the column by the mobile phase. As the solvent is forced by the flow rate, the sample separates into various zones of sample components and is referred to band.

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