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The method for determining molecular weight based on the size is __________

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The method for determining molecular weight based on the size is __________

(a) mass spectrometry

(b) ultracentrifugation

(c) gel filtration

(d) biosensor

The question was posed to me during an online interview.

The question is from Determination of Molecular Weight of Enzymes topic in portion Enzyme Extraction and Purification of Enzyme Technology

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The correct choice is (c) gel filtration

To explain I would say: The method for determining molecular weight based on the size is gel filtration. Ultracentrifugation is method that determines the molecular weight based on the sedimentation rate of particles. Mass spectrometry is a method to determine molecular weight based on the charge to mass ratio. Biosensor is an analytical device which converts a biological response into an electrical signal.

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