Question

When a series of deleted regions are replaced by some other DNA fragment of equal length, then it is known as:

(a) linker scanning

(b) generation of deletions

(c) mutation

(d) replacement

I had been asked this question during a job interview.

My question is taken from Removal and Introduction of Restriction Sites and Generation of Insertions and Deletions in chapter Modifications and Mutagenesis of Genetic Engineering

Answer 1

The correct choice is (a) linker scanning

To explain I would say: Sometimes, a series of deleted regions are replaced by a fragment of DNA of equal length, then it is called as linker scanning. It is done in order to not disrupt the spacing between control regions.