Question

Introduction into host organism can also be done by using a DNA construct, which when transcribed, generates an RNA which is _________

(a) circular

(b) linear

(c) double stranded

(d) self-complementary

I had been asked this question during an internship interview.

I'm obligated to ask this question of Post-transcriptional Gene Silencing topic in division Modifications and Mutagenesis of Genetic Engineering

Answer 1

The correct choice is (d) self-complementary

Best explanation: Introduction into the host organism can also be done by using a DNA construct, which when transcribed, generates a RNA which is self-complementary. It leads to the formation of double stranded RNA and is capable of activating RNAi effect.