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Which of the following is not an inhibitor of pyruvate dehydrogenase in conversion pyruvate to acetyl CoA?

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+1 vote
in Enzyme Technology by (55.0k points)
Which of the following is not an inhibitor of pyruvate dehydrogenase in conversion pyruvate to acetyl CoA?

(a) Citrate

(b) ATP

(c) NADH

(d) Acetyl CoA

I had been asked this question in examination.

Question is taken from Allosteric Enzyme topic in portion Enzymes of Enzyme Technology

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Best answer
Correct choice is (a) Citrate

The best explanation: Citrate acts as activator for acetyl CoA carboxylase in fatty acid synthesis. Inhibitors of pyruvate dehydrogenase in conversion pyruvate to acetyl CoA are ATP, NADH and Acetyl CoA.

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