Question

Which step of pentose phosphate pathway in represented in the following diagram?

(a) Oxidative step

(b) Renin conversion step

(c) Non-oxidative step

(d) Angiotensin conversion step

The question was posed to me in final exam.

My doubt stems from Clinical Significance of Angiotensin Converting Enzyme and Glucose-6-phosphate Dehydrogenase topic in portion Clinical Enzymology of Enzyme Technology

Answer 1

The correct option is (c) Non-oxidative step

To explain: Non-oxidative step of pentose phosphate pathway is represented in the above diagram. Ribulose-5-phosphate from oxidative step and xylulose-5-phosphate react with each other in presence of transketolase to produce pseudoheptulose-7-phosphate and glyceraldehye-3-phosphate. This is converted erythrose-4-phosphate and fructose-6-phosphate by transidolase enzyme. In the presence of transketolase and reaction with xylulose-5-phosphate, glyceraldehyde-3-phosphate.