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In the following diagram, which kind of inhibition is represented?

(a) Uncompetitive inhibition

(b) Competitive inhibition

(c) Non-competitive inhibition

(d) Mixed inhibition

I had been asked this question during an interview.

The above asked question is from Fundamentals in portion Enzyme Kinetics Fundamentals of Enzyme Technology

1 Answer

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Correct choice is (b) Competitive inhibition

To explain: In the above diagram, it is shown that both substrate and inhibitor compete for the active site of the enzyme with formation of enzyme-inhibitor [EI] complex rather than enzyme-substrate-inhibitor [ESI] complex. Hence the inhibition shown in the diagram is competitive inhibition. It usually occurs at low substrate concentrations, but can be overcome at high substrate concentration.

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