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Inhibition of lactase by galactose is an example of which kind of inhibition?

(a) Uncompetitive inhibition

(b) Mixed inhibition

(c) Competitive inhibition

(d) Substrate inhibition

The question was asked during an internship interview.

This key question is from Fundamentals in chapter Enzyme Kinetics Fundamentals of Enzyme Technology

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Correct choice is (c) Competitive inhibition

Easiest explanation: In competitive inhibition, the inhibitor is having structural similarity to substrate, and often is a reaction product. As lactose and galactose have structural similarity, they exhibit competitive inhibition. Substrate inhibition is a case uncompetitive inhibition. Uncompetitive inhibition occurs wherein one substrate is competitive and other substrate is non-competitive with respect to the enzyme. Mixed inhibition is said to occur when both enzyme-inhibitor and enzyme-substrate-inhibitor complexes are formed.

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