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The rate of enzyme catalyzed reaction decreases with an increase in ionic strength if the charges are identical.

(a) True

(b) False

I have been asked this question in my homework.

My question comes from Enzyme Kinetics Fundamentals topic in chapter Enzyme Kinetics Fundamentals of Enzyme Technology

1 Answer

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Best answer
Right answer is (b) False

To explain: The ionic strength depends on the binding of charged substrates to enzyme and movement of charged groups within the catalytic site. If the rate of the reaction depends on charged moieties, the rate of the reaction may be given as, log⁡(k)=log⁡(k0)+ZA ZB \(\sqrt{I}\)  

Where, k = rate constant, k0 = rate constant at zero ionic strength, ZA and ZB = electrostatic charges on reacting species, I = ionic strength of the solution.

If the charges are opposite, there is a decrease in rate of reaction with increasing ionic strength. When the charges are opposite, there is an increase in rate of reaction with increasing ionic strength.

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