Question

Which pathway is represented in the following diagram?

(a) Purine degradation pathway

(b) Glycolysis

(c) Renin angiotensin aldosterone pathway

(d) TCA cycle

I got this question during an internship interview.

I need to ask this question from Clinical Significance of Angiotensin Converting Enzyme and Glucose-6-phosphate Dehydrogenase in division Clinical Enzymology of Enzyme Technology

Answer 1

Correct answer is (c) Renin angiotensin aldosterone pathway

The best explanation: The pathway represented in the above diagram is renin angiotensin aldosterone pathway. The initial stimuli for this pathway is dehydration which leads to decrease in blood volume and blood pressure. This stimulates the juxtaglomerular cells secrete renin which converts angiotensin to angiotensin I. ACE converts to angiotensin I to angiotensin II. Thus increases its level. This increase stimulates adrenal cortex to secrete aldosterone. This leads to reabsorption of water and sodium which increase blood volume and BP raises to normal.