Correct choice is (a) Cannabidiol
To explain I would say: Cannabidiol not Generally Regarded as Safe (GRAS) by the FDA, USA. Whereas catalase, papain, trypsin is Generally Regarded as Safe (GRAS) by the FDA, USA. Other approved enzymes are α-amylase, β-amylase, bromelain, cellulase, ficin, α-galactosidase, glucoamylase, glucose isomerase, glucose oxidase, invertase, lactase, lipase, pectinase, pepsin and rennet.