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Which of the following is not Generally Regarded as Safe (GRAS) by the FDA, USA?

(a) Cannabidiol

(b) Catalase

(c) Papain

(d) Trypsin

The question was asked in examination.

This is a very interesting question from Safety and Regulatory Aspects of Enzyme Use topic in section Enzyme Preparation and Usage of Enzyme Technology

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Correct choice is (a) Cannabidiol

To explain I would say: Cannabidiol not Generally Regarded as Safe (GRAS) by the FDA, USA. Whereas catalase, papain, trypsin is Generally Regarded as Safe (GRAS) by the FDA, USA. Other approved enzymes are α-amylase, β-amylase, bromelain, cellulase, ficin, α-galactosidase, glucoamylase, glucose isomerase, glucose oxidase, invertase, lactase, lipase, pectinase, pepsin and rennet.

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