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Which of these is not a hydrophilic polymer used to stabilize enzymes?

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Which of these is not a hydrophilic polymer used to stabilize enzymes?

(a) Polyvinyl alcohol

(b) Polyvinylpyrrolidone

(c) Mannitol

(d) Hydroxypropylcelluloses

I have been asked this question at a job interview.

My question is taken from Enzyme Preparation for Sale topic in section Enzyme Preparation and Usage of Enzyme Technology

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Right answer is (c) Mannitol

Easiest explanation: Mannitol is a low molecular weight polyol that is used to stabilize enzymes. Polyvinyl alcohol, polyvinylpyrrolidone and hydroxypropylcelluloses are hydrophilic polymers which stabilize enzymes in the following ways:

• A process of compartmentalization wherein the enzyme-enzyme and enzyme-water interactions are replaced by less potentially denaturing enzyme-polymer interactions.

• By stabilizing the hydrophobic effect within the enzymes.

• By specific chemical modifications of amino acid side chains are possible which may result in stabilization.

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