Question

Which of the following is not true for coenzymes?

(a) Coenzymes may be immobilized/regenerated with the use of whole-cell systems

(b) Membrane reactors may be used to immobilize the coenzyme

(c) They are referred to as artificial enzymes

(d) Coenzymes may be derivatized for adequate immobilization and regeneration

The question was posed to me by my college director while I was bunking the class.

This intriguing question originated from Future Prospects in chapter Enzyme Technology Future Prospects of Enzyme Technology

Answer 1

The correct option is (c) They are referred to as artificial enzymes

Explanation: Synzymes are also referred to as artificial enzymes, and not coenzymes. Hence this statement is not true for coenzymes. The statements which are true are as follows:

• Coenzymes may be immobilized/regenerated with the use of whole-cell systems. But, these have lower efficiency and flexibility as compared to immobilised-enzyme systems

• Membrane reactors may be used to immobilize the coenzyme. but the pore size of the reactor must be smaller than the coenzyme diameter, which may be extremely restrictive.

• Coenzymes may be derivatized for adequate immobilization and regeneration. This process activates the coenzymes so that it attaches to the support, but does not interfere with its biological function.