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Chromosomal or genomic DNA is separated by ____________

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in Genetic Engineering by (118k points)
Chromosomal or genomic DNA is separated by ____________

(a) Sedimentation

(b) Dissolution in water

(c) Centrifugation

(d) Distillation

I had been asked this question in an interview for job.

Query is from Purification of Plasmid DNA in section Basics of Genetic Engineering of Genetic Engineering

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The correct choice is (c) Centrifugation

To elaborate: Chromosomal or genomic DNA is comparatively heavier and large in size than that of plasmid DNA. Hence, centrifuging at a high speed leads to settling down of the genomic DNA and thus can be separated easily.

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