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Which of the following is a physical method of cell disruption?

(a) Using detergents

(b) Using solvents

(c) Using French press

(d) Using osmotic shock

This question was posed to me in semester exam.

Query is from Fermentation Laboratory topic in portion Equipping a Fermentation Laboratory, the Design and Preparation of Media for Bioprocesses of Fermentation Technology

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Correct answer is (c) Using French press

For explanation I would say: The physical method of cell disruption is using a French press. Other physical methods include bead mill, colloid mill, ultrasonic vibrations, etc. Using detergents, solvents, enzymes, the osmotic shock is an example of chemical cell disruption.

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