Question

Which of the following is not a rule while doing scale-up studies?

(a) The similarity in the geometry of the fermenter used

(b) The similarity in the configuration of the fermenter used

(c) There should a minimum of three or four stages of increment

(d) Increasing power is a jump in scale

The question was posed to me by my school teacher while I was bunking the class.

My doubt stems from Aeration and Agitation topic in portion Aeration and Agitation of Fermentation Technology

Answer 1

Correct answer is (d) Increasing power is a jump in scale

The explanation is: Increasing the power or magnitude is not a jump in scale. The jump in scale means performing laboratory-scale experiments at a pilot-scale or industrial scale-level. The geometry and the configuration of the fermenters used at both scales should be the same.