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What does the following reaction represent?

(a) Hydrogenation

(b) Kinetically controlled synthesis

(c) Substitution

(d) Decomposition

The question was asked by my college director while I was bunking the class.

This intriguing question comes from Recent Advances topic in division Recent Advances in Enzyme Technology of Enzyme Technology

1 Answer

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Correct answer is (b) Kinetically controlled synthesis

To elaborate: The above reaction represents kinetically controlled synthesis. Kinetically controlled synthesis is one wherein the rate of peptide product synthesis (kP) is high compared to that of the rate of peptide hydrolysis (kH). By providing an amino acid or peptide which is a more powerful nucleophile than water in accepting a peptide unit from an enzyme-peptide intermediate, kinetically controlled synthesis may be achieved. In the reaction, X represents an alcohol, amine or other activating group, i.e., the reactant is an ester, amide (peptide) or activated carboxylic acid.

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