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If a gene is inactivated by gene targeting then it is called as ____________

(a) knock-in gene

(b) knock-out gene

(c) gene disruption

(d) insertional inactivation

The question was posed to me during a job interview.

Asked question is from Generation of Transgenic Organsims in portion Using Other Organisms of Genetic Engineering

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The correct answer is (b) knock-out gene

Easy explanation: If a gene is inactivated by gene targeting then it is called a knock-out gene. If a gene is replaced by some other gene then it is called as knocking in.

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