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How does Bacteria develop resistance mechanisms?

(a) Extracellular ligands

(b) Intercellular ligands

(c) Instructions by DNA

(d) Integral proteins

I have been asked this question during an interview.

Enquiry is from Genetic Aspects of Heavy Metal Resistance in division Microbial Transformation of Heavy Metals of Environmental Biotechnology

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The correct answer is (c) Instructions by DNA

For explanation: Bacteria uses instructions from there DNA that leads to the development of resistance mechanisms in them. In bacteria, the resistance genes are found within plasmids, small pieces of DNA that carry genetic instructions. Bacteria doesn’t develop resistance mechanisms by extracellular ligands, Integral proteins or Intercellular ligands.

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